Fast disinfecting antimicrobial surfaces

Langmuir. 2009 Jan 20;25(2):1060-7. doi: 10.1021/la802953v.


Silicon wafers and glass surfaces were functionalized with facially amphiphilic antimicrobial copolymers using the "grafting from" technique. Surface-initiated atom transfer radical polymerization (ATRP) was used to grow poly(butylmethacrylate)-co-poly(Boc-aminoethyl methacrylate) from the surfaces. Upon Boc-deprotection, these surfaces became highly antimicrobial and killed S. aureus and E. coli 100% in less than 5 min. The molecular weight and grafting density of the polymer were controlled by varying the polymerization time and initiator surface density. Antimicrobial studies showed that the killing efficiency of these surfaces was independent of polymer layer thickness or grafting density within the range of surfaces studied.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Escherichia coli / drug effects
  • Glass / chemistry
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Particle Size
  • Polymethacrylic Acids / chemical synthesis
  • Polymethacrylic Acids / chemistry*
  • Polymethacrylic Acids / pharmacology
  • Silicon / chemistry*
  • Staphylococcus aureus / drug effects
  • Surface Properties


  • Anti-Bacterial Agents
  • Polymethacrylic Acids
  • poly(butylmethacrylate)-co-poly(Boc-aminoethyl methacrylate)
  • Silicon