Restored cardiac conditions and left ventricular function after parathyroidectomy in a hemodialysis patient. Parathyroidectomy improves cardiac fatty acid metabolism assessed by 123I-BMIPP

Circ J. 2009 Oct;73(10):1956-60. doi: 10.1253/circj.cj-08-0415. Epub 2009 Jan 27.


A 62 year-old female hemodialysis patient underwent parathyroidectomy to treat secondary hyperparathyroidism. On the preoperative assessment, the plasma levels of parathyroid hormone (PTH) and B-type natriuretic peptide (BNP) were elevated. Echocardiography showed reduced left ventricular (LV) contraction. Myocardial iodine-123-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid ((123)I-BMIPP) scintigraphy showed moderately reduced tracer uptake in the postero-inferior area on single-photon emission computed tomography and decreased washout on the planar images. After parathyroidectomy, the plasma levels of PTH and BNP decreased, followed by improvement in LV contraction. Myocardial (123)I-BMIPP scintigraphy revealed that the washout on planar images had increased, which suggests that myocardial (123)I-BMIPP scintigraphy is useful for estimating the effect of parathyroidectomy on cardiac function.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers / blood
  • Echocardiography
  • Fatty Acids / metabolism*
  • Female
  • Humans
  • Hyperparathyroidism, Secondary / etiology
  • Hyperparathyroidism, Secondary / metabolism
  • Hyperparathyroidism, Secondary / surgery*
  • Iodine Radioisotopes
  • Iodobenzenes*
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / metabolism
  • Kidney Failure, Chronic / therapy
  • Middle Aged
  • Myocardial Contraction
  • Myocardium / metabolism*
  • Natriuretic Peptide, Brain / blood
  • Parathyroid Hormone / blood
  • Parathyroidectomy*
  • Radiopharmaceuticals*
  • Recovery of Function
  • Renal Dialysis*
  • Stroke Volume
  • Tomography, Emission-Computed, Single-Photon
  • Treatment Outcome
  • Ventricular Dysfunction, Left / diagnostic imaging*
  • Ventricular Dysfunction, Left / etiology
  • Ventricular Dysfunction, Left / metabolism
  • Ventricular Dysfunction, Left / physiopathology
  • Ventricular Function, Left*


  • Biomarkers
  • Fatty Acids
  • Iodine Radioisotopes
  • Iodobenzenes
  • Parathyroid Hormone
  • Radiopharmaceuticals
  • iodofiltic acid
  • Natriuretic Peptide, Brain