[Research on the effect of phenylethanoid glycosides (PEG) of the Cistanche deserticola on anti-aging in aged mice induced by D-galactose]

Zhong Yao Cai. 2008 Sep;31(9):1385-8.
[Article in Chinese]


Objective: To investigate the effect of Phenylethanoid glycosides (PEG) of the Cistanche deserticola on anti-aging in aged mice induced by D-galactose.

Methods: Taking Vitamin E as the positive control, after administration of high and low dose of the PEG, detected the learning and memory ability, the activities of SOD, the content of MDA and organ index.

Results: Compared with the model group, the abilities of learning and memorizing were improved in PEG groups. The activity of SOD was enhanced significantly in serum and brain. The MDA content of liver and serum was decreased. The PEG also improved the Index of spleen and thymus.

Conclusion: The PEG of Cistanche deserticola can enhance the ability of learning, memorizing, anti-oxidation, and improve immune function.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / drug effects*
  • Aging / metabolism
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Cistanche* / chemistry
  • Disease Models, Animal
  • Female
  • Galactose
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Learning / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Malondialdehyde / blood
  • Malondialdehyde / metabolism
  • Memory / drug effects
  • Mice
  • Mice, Inbred ICR
  • Oxidative Stress / drug effects
  • Superoxide Dismutase / blood
  • Superoxide Dismutase / metabolism*


  • Glycosides
  • Malondialdehyde
  • Superoxide Dismutase
  • Galactose