Mutagenicity of water-soluble ZnO nanoparticles in Ames test

J Toxicol Sci. 2009 Feb;34(1):119-22. doi: 10.2131/jts.34.119.

Abstract

A mutagenicity test was conducted on water-soluble ZnO nanoparticles capped with tetramethylammonium hydroxide in a bacterial reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537, and Escherichia coli strain WP2uvrA(-), with and without metabolic activation by S9 mix in the preincubation method. Mutagenicity was negative in all strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Male
  • Microsomes, Liver / enzymology
  • Mutagenicity Tests / methods*
  • Mutagens / chemistry
  • Mutagens / toxicity*
  • Nanoparticles / chemistry
  • Nanoparticles / toxicity*
  • Particle Size
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / toxicity
  • Rats
  • Rats, Sprague-Dawley
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / growth & development
  • Solubility
  • Water
  • Zinc Oxide / chemistry
  • Zinc Oxide / toxicity*

Substances

  • Mutagens
  • Quaternary Ammonium Compounds
  • Water
  • tetramethylammonium
  • Zinc Oxide