The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis

RNA Biol. Jul-Sep 2008;5(3):115-9. doi: 10.4161/rna.5.3.6558.

Abstract

MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Epithelium / pathology*
  • Humans
  • Mesoderm / pathology*
  • MicroRNAs / metabolism*
  • Neoplasm Metastasis / genetics*
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Transcription Factors / metabolism

Substances

  • MicroRNAs
  • Transcription Factors