A new class of murine leukemia virus associated with development of spontaneous lymphomas

Proc Natl Acad Sci U S A. 1977 Feb;74(2):789-92. doi: 10.1073/pnas.74.2.789.


A new type of murine leukemia virus has been detected in thymuses of leukemic and late preleukemic AKR mice, in lymphomas developing in NIH Swiss mice carrying the AKR ectopic virus-inducing loci Akv-I or Akv-2, and in the thymus of a preleukemic C58 mouse. The viruses induce focal areas of morphologic alteration in a mink lung cell line and are tentatively referred to as "mink cell focus-inducing" (MCF) strains. They have the host range of both xenotropic and N-tropic ecotropic murine leukemia viruses, are neutralized by antisera to both ecotropic and xenotropic viruses, and are interfered with by both viruses. They may represent a particular type of genetic recombinant which emerges during the preleukemic period in high-ecotropic-virus mouse strains, and they may play a significant role in the etiology of spontaneous lymphomas.

MeSH terms

  • Animals
  • Cell Line
  • Cytopathogenic Effect, Viral
  • Leukemia Virus, Murine / pathogenicity*
  • Lymphoma / microbiology*
  • Mice
  • Mice, Inbred AKR
  • Neoplasm Transplantation
  • Neoplasms, Experimental