Topical prostaglandin analogues do not affect selective laser trabeculoplasty outcomes

Eye (Lond). 2009 Dec;23(12):2194-9. doi: 10.1038/eye.2009.1.


Purpose: To investigate the effect of topical prostaglandin analogue use on the efficacy of selective laser trabeculoplasty (SLT) intraocular pressure (IOP) lowering in patients with open-angle glaucoma.

Patients and methods: This retrospective study included 123 consecutive patients who underwent 180 degrees SLT for the first time. Eyes were grouped into those that received prostaglandin analogues before and after SLT (n=74) and those that did not (n=49). The main outcome measure was IOP lowering after SLT. Success was defined as > or =20% reduction in IOP without further glaucoma intervention.

Results: There was no significant difference in IOP lowering at 6 months post-laser between the prostaglandin and non-prostaglandin groups (3.9+/-4.8 vs 4.6+/-3.6 mm Hg, P=0.43). Long-term SLT success rates were also not significantly different between the treatment groups (Kaplan-Meier survival analysis, P=0.68). IOP lowering at 6 months was similar in eyes that received no glaucoma medications, monotherapy with or without a prostaglandin analogue, or combination therapy with or without prostaglandin analogues (P=0.81). Logistic regression analysis showed that various patient characteristics including age, sex, type of glaucoma, previous glaucoma surgery, and other glaucoma risk factors did not predict a successful SLT outcome. However, higher pre-operative IOP was found to predict SLT success (odds ratio=1.12, 95% CI=1.02-1.24, P=0.02).

Conclusion: The IOP lowering efficacy of SLT is not influenced by the use of topical prostaglandin analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Amides / therapeutic use
  • Antihypertensive Agents / therapeutic use*
  • Bimatoprost
  • Cloprostenol / analogs & derivatives
  • Cloprostenol / therapeutic use
  • Glaucoma, Open-Angle / drug therapy*
  • Glaucoma, Open-Angle / physiopathology
  • Glaucoma, Open-Angle / surgery
  • Humans
  • Intraocular Pressure / drug effects
  • Intraocular Pressure / physiology
  • Kaplan-Meier Estimate
  • Laser Therapy
  • Latanoprost
  • Logistic Models
  • Outcome Assessment, Health Care
  • Prostaglandins / therapeutic use*
  • Prostaglandins F, Synthetic / therapeutic use
  • Retrospective Studies
  • Risk Factors
  • Trabecular Meshwork / surgery*
  • Trabeculectomy / methods*
  • Travoprost


  • Amides
  • Antihypertensive Agents
  • Prostaglandins
  • Prostaglandins F, Synthetic
  • Cloprostenol
  • Latanoprost
  • Bimatoprost
  • Travoprost