The precision of remote context memories does not require the hippocampus

Nat Neurosci. 2009 Mar;12(3):253-5. doi: 10.1038/nn.2263. Epub 2009 Feb 1.


Although the clarity of many memories fades with time, some memories may maintain their original precision. Here we used a context discrimination procedure to evaluate whether the hippocampus is important in maintaining precision as memories mature. Spared discrimination in hippocampal-lesioned mice indicated that precise, remote context memories may be supported by extra-hippocampal brain regions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Discrimination Learning / physiology*
  • Fear / physiology
  • Hippocampus / physiology*
  • Male
  • Maze Learning / physiology
  • Memory / physiology*
  • Mental Recall / physiology
  • Mice
  • Mice, Inbred C57BL
  • Time Factors