Variant in the sequence of the LINGO1 gene confers risk of essential tremor

Nat Genet. 2009 Mar;41(3):277-9. doi: 10.1038/ng.299. Epub 2009 Feb 1.


We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Austria
  • Essential Tremor / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genetics, Population
  • Genome-Wide Association Study
  • Germany
  • Humans
  • Iceland
  • Linkage Disequilibrium
  • Membrane Proteins / genetics*
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Single Nucleotide / physiology
  • Risk Factors
  • United States


  • LINGO1 protein, human
  • Membrane Proteins
  • Nerve Tissue Proteins