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. 2009 Mar;41(3):277-9.
doi: 10.1038/ng.299. Epub 2009 Feb 1.

Variant in the Sequence of the LINGO1 Gene Confers Risk of Essential Tremor

Free PMC article

Variant in the Sequence of the LINGO1 Gene Confers Risk of Essential Tremor

Hreinn Stefansson et al. Nat Genet. .
Free PMC article

Erratum in

  • Nat Genet. 2009 Apr;41(4):504


We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]


Figure 1
Figure 1
Overview of the 185-kb region around rs9652490. (a) Single marker association results from both the genome-wide scan of Icelandic subjects with essential tremor (red circles) and the combined analysis including four follow-up datasets (blue circles). P values are corrected for relatedness and potential population stratification. (b) Exon structure of the LINGO1 gene. The associated marker is located in intron 3 of the gene. (c) Pairwise correlation coefficient (r2) from the CEU HapMap population.

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