Inflammation and cancer: IL-6 and STAT3 complete the link

Cancer Cell. 2009 Feb 3;15(2):79-80. doi: 10.1016/j.ccr.2009.01.009.


There is growing evidence that tumors are sustained and promoted by inflammatory signals from the surrounding microenvironment. Two papers by Grivennikov et al. and Bollrath et al. in this issue of Cancer Cell demonstrate the importance of the interleukin-6 family of proinflammatory cytokines and their downstream effector STAT3 in colitis-associated colon cancer.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autocrine Communication / physiology
  • Colonic Neoplasms / immunology*
  • Cytokine Receptor gp130 / metabolism
  • Humans
  • Inflammation / metabolism*
  • Interleukin-6 / immunology*
  • Models, Biological
  • STAT3 Transcription Factor / immunology*
  • Signal Transduction / physiology


  • Interleukin-6
  • STAT3 Transcription Factor
  • Cytokine Receptor gp130