Identifying the perpetrator in medulloblastoma: Dorian Gray versus Benjamin Button

Cancer Cell. 2009 Feb 3;15(2):83-5. doi: 10.1016/j.ccr.2009.01.010.


Tumors contain a subpopulation of tumor-propagating cells (TPCs) that are critical for their growth. In this issue, Read, Wechsler-Reya, and colleagues show that in an animal model of medulloblastoma, TPCs express the surface marker CD15 and have properties distinct from neural stem cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Neoplasm / metabolism
  • Cerebellar Neoplasms* / pathology
  • Cerebellar Neoplasms* / physiopathology
  • Humans
  • Lewis X Antigen / metabolism
  • Medulloblastoma* / pathology
  • Medulloblastoma* / physiopathology
  • Mice
  • Neoplastic Stem Cells* / pathology
  • Neoplastic Stem Cells* / physiology


  • Antigens, Neoplasm
  • Lewis X Antigen