Nanoparticle-based targeted drug delivery

Exp Mol Pathol. 2009 Jun;86(3):215-23. doi: 10.1016/j.yexmp.2008.12.004. Epub 2009 Jan 7.


Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the "nanometer" size range. These nano-sized objects, e.g., "nanoparticles", take on novel properties and functions that differ markedly from those seen from items made of identical materials. The small size, customized surface, improved solubility, and multi-functionality of nanoparticles will continue to open many doors and create new biomedical applications. Indeed, the novel properties of nanoparticles offer the ability to interact with complex cellular functions in new ways. This rapidly growing field requires cross-disciplinary research and provides opportunities to design and develop multifunctional devices that can target, diagnose, and treat devastating diseases such as cancer. This article presents an overview of nanotechnology for the biologist and discusses the attributes of our novel XPclad((c)) nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Dendrimers
  • Drug Delivery Systems / methods*
  • Humans
  • Hydrogels
  • Liposomes
  • Micelles
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Nanotechnology
  • Neoplasms / drug therapy
  • Quantum Dots


  • Antineoplastic Agents
  • Dendrimers
  • Hydrogels
  • Liposomes
  • Micelles