Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 35 (7), 1152-70

The Impact of Obesity on Outcomes After Critical Illness: A Meta-Analysis


The Impact of Obesity on Outcomes After Critical Illness: A Meta-Analysis

Charles W Hogue Jr et al. Intensive Care Med.


Purpose: To assess whether obesity is associated with mortality or other adverse intensive care unit (ICU) and post-ICU outcomes.

Methods: A meta-analysis of studies from PubMed and EMBASE databases.

Results: Twenty-two studies (n = 88,051 patients) were included. Pooled analysis demonstrated no difference in ICU mortality, but lower hospital mortality for obese and morbidly obese subjects (RR 0.76; 95% CI 0.59, 0.92; RR 0.83; 95% CI 0.66, 1.04, respectively) versus normal weight subjects. There was no association between obesity and duration of mechanical ventilation or ICU stay. Morbidly obese versus normal weight patients had longer hospitalizations. No study reported physical function, mental health, or quality of life outcomes after discharge.

Conclusions: Obesity is not associated with increased risk for ICU mortality, but may be associated with lower hospital mortality. There is a critical lack of research on how obesity may affect complications of critical illness and patient long-term outcomes.

Similar articles

See all similar articles

Cited by 68 PubMed Central articles

See all "Cited by" articles


    1. Ann Intern Med. 2004 Mar 2;140(5):338-45 - PubMed
    1. Chest. 2004 Apr;125(4):1441-5 - PubMed
    1. Crit Care Med. 2005 Jul;33(7):1549-56 - PubMed
    1. Anaesth Intensive Care. 2006 Oct;34(5):629-33 - PubMed
    1. J Am Coll Surg. 2006 Oct;203(4):533-8 - PubMed