Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cells to Differentiate Into CD8+ T Lymphocytes in Lung Tissue via Up-Regulating Notch1 Expression

Cancer Res. 2009 Feb 15;69(4):1578-86. doi: 10.1158/0008-5472.CAN-08-2744. Epub 2009 Feb 3.

Abstract

Suppressor of cytokine signaling 3 (SOCS3) expression in bone marrow cells (BMC) was up-regulated upon exposure to interleukin 6, lipopolysaccharide, or tumor-associated factors. But, how the up-regulated SOCS3 affects differentiation of BMCs is incompletely characterized. Here, we showed that SOCS3 promoted BMCs to intently differentiate into CD8 T cells. Importantly, lung can be as one athymus tissue for the BMCs to differentiate into CD8(+) T cells. Notch1 plays a critical role in the differentiation from SOCS3-transfected BMCs to CD8(+) T cells. We conclude that the up-regulated SOCS3 in some pathologic conditions, such as tumor and inflammation, might promote BMCs to differentiate into CD8(+) T lymphocytes in lung tissue via up-regulating Notch1 expression. This may represent a new mechanism against diseases such as tumor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology*
  • Bone Marrow Cells / drug effects
  • Bone Marrow Cells / immunology*
  • CD8-Positive T-Lymphocytes / drug effects
  • CD8-Positive T-Lymphocytes / immunology*
  • Cell Differentiation / immunology*
  • Cell Line
  • Coculture Techniques
  • Female
  • Gene Expression
  • Humans
  • Inflammation / immunology
  • Interleukin-6 / pharmacology
  • Lung / immunology*
  • Lung Neoplasms / immunology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Nude
  • Ovary
  • Receptor, Notch1 / genetics*
  • Stromal Cells / immunology
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins / physiology*

Substances

  • Interleukin-6
  • Notch1 protein, mouse
  • Receptor, Notch1
  • Socs3 protein, mouse
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins