Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment

Clin Infect Dis. 2009 Mar 1;48(5):e53-6. doi: 10.1086/597011.


Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anal Canal / microbiology
  • Anti-Bacterial Agents / therapeutic use*
  • Chlamydia trachomatis / drug effects*
  • Chlamydia trachomatis / isolation & purification
  • DNA, Bacterial / isolation & purification
  • Doxycycline / therapeutic use*
  • Humans
  • Lymphogranuloma Venereum / drug therapy*
  • Male
  • Proctitis / drug therapy*
  • RNA, Bacterial / isolation & purification
  • Time Factors


  • Anti-Bacterial Agents
  • DNA, Bacterial
  • RNA, Bacterial
  • Doxycycline