Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity

Lung Cancer. 2009 Jul;65(1):119-22. doi: 10.1016/j.lungcan.2008.12.020. Epub 2009 Feb 4.


Spontaneous remission of malignant tumors is rare and the biological mechanism of such remission has not been addressed. We report the case of a 71-year-old Japanese patient with non-small cell lung cancer with a right hilar tumor and pleural dissemination that spontaneously regressed. NY-ESO-1 is a cancer/testis antigen that can elicit specific immune responses in patients with cancer. Strong anti-NY-ESO-1 immunity was detected in this patient. His tumor cells expressed NY-ESO-1 and MHC class I molecules. Anti-NY-ESO-1 immunity might have contributed to spontaneous remission in this patient.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Neoplasm / immunology*
  • Carcinoma, Non-Small-Cell Lung / immunology*
  • Female
  • Forkhead Transcription Factors / immunology
  • Humans
  • Interleukin-2 Receptor alpha Subunit / immunology
  • Lung Neoplasms / immunology*
  • Membrane Proteins / immunology*
  • Neoplasm Regression, Spontaneous*
  • T-Lymphocytes / immunology


  • Antigens, Neoplasm
  • CTAG1B protein, human
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • IL2RA protein, human
  • Interleukin-2 Receptor alpha Subunit
  • Membrane Proteins