Acute biopsy-proven lymphocytic myocarditis mimicking Takotsubo cardiomyopathy

Eur J Heart Fail. 2009 Apr;11(4):428-31. doi: 10.1093/eurjhf/hfp008. Epub 2009 Feb 3.


Endomyocardial biopsy (EMB), the diagnostic gold standard for myocarditis, has not been systematically performed in the reported case series of Takotsubo cardiomyopathy, although proposed Mayo Criteria specify exclusion of myocarditis. Moreover, there is no specific recommendation for infarct-like acute myocarditis in the recently published guidelines on the role of EMB. Here we present a thoroughly documented case fulfilling both the proposed Mayo criteria for Takotsubo cardiomyopathy and the World Health Organization criteria for active, virus-negative, immune-mediated myocarditis. Since myocarditis can mimic acute myocardial infarction with normal coronary arteries, EMB should be performed to rule out myocarditis in patients presenting with LV apical ballooning syndrome (or Takotsubo cardiomyopathy).

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Biopsy / methods*
  • Diagnosis, Differential
  • Echocardiography
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Myocarditis / pathology*
  • Myocarditis / physiopathology
  • Myocardium / pathology*
  • Stroke Volume / physiology
  • Takotsubo Cardiomyopathy / diagnosis*