Diffuse large B-cell lymphoma with coexpression of CD3 in a pediatric patient: a case report, review of the literature, and tissue microarray study

J Pediatr Hematol Oncol. 2009 Feb;31(2):124-7. doi: 10.1097/MPH.0b013e31818b354a.

Abstract

The aberrant expression of T-cell antigens on B-cell-derived non-Hodgkin lymphomas has been described. However, the expression of the lineage-specific T-cell antigen, CD3, in hematologic malignancies is exceedingly rare and to the best of our knowledge has not been reported in pediatric patients. Here we describe the first case of a CD3+ diffuse large B-cell lymphoma in a 9-year-old male patient that is well documented by immunohistochemistry. In addition, results of a tissue microarray study composed of B-cell-derived non-Hodgkin lymphomas (n=77) and reactive lymphoid hyperplasia (n=13) dual stained for PAX5/CD3 are also reported.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes / pathology
  • CD3 Complex*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunophenotyping
  • Infant
  • Lymphoma, B-Cell / pathology
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Male
  • Middle Aged
  • Pseudolymphoma / pathology
  • Tissue Array Analysis
  • Young Adult

Substances

  • CD3 Complex