Evaluation of Three Commercial Latex Agglutination Kits and a Commercial Enzyme Immunoassay for the Detection of Cryptococcal Antigen

Med Mycol. 2009 May;47(3):336-8. doi: 10.1080/13693780802607400. Epub 2009 Feb 4.

Abstract

We compared the performance of the Meridian CALAS, Wampole Crypto-LA, Murex Cryptococcus latex agglutination assay, and the Meridian Premier EIA for the detection of cryptococcal antigen in serum and CSF. The assays demonstrated similar performance characteristics based on concordance values > or = 93% but important differences were noted in endpoint titers.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Antigens, Fungal / analysis*
  • Clinical Laboratory Techniques / methods*
  • Cryptococcosis / diagnosis*
  • Immunoenzyme Techniques / methods
  • Latex Fixation Tests / methods
  • Reagent Kits, Diagnostic*
  • Sensitivity and Specificity
  • Serum / chemistry*
  • Serum / microbiology

Substances

  • Antigens, Fungal
  • Reagent Kits, Diagnostic