Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation

Cancer Invest. 2009 Mar;27(3):251-6. doi: 10.1080/07357900802254016.


Thymosin beta-10 (T beta 10) has been shown to be associated with several cancers; however, its role in pancreatic cancer is not understood. The expression of T beta 10 was determined by immunohistochemistry and real-time polymerase chain reaction. The phosphorylation of JNK and the cytokine secretion was determined by using the Bio-Plex phosphoprotein and cytokines assays. Pancreatic cancer tissues and cells expressed higher amounts of T beta 10 than normal surrounding tissues and human pancreatic duct epithelial cells. Exogenous T beta 10 caused the phosphorylation of JNK and increased the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 cells. T beta 10 might be a promising marker and a novel therapeutic target for pancreatic cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cytokines / biosynthesis
  • Enzyme Activation
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism*
  • MAP Kinase Signaling System / physiology
  • Pancreatic Neoplasms / immunology*
  • Pancreatic Neoplasms / pathology
  • Phosphorylation
  • Thymosin / analysis
  • Thymosin / genetics
  • Thymosin / physiology*


  • Cytokines
  • Thymosin
  • thymosin beta(10)
  • JNK Mitogen-Activated Protein Kinases