Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

Mol Nutr Food Res. 2009 May:53 Suppl 1:S7-15. doi: 10.1002/mnfr.200800177.


This was a double-blind, randomised, placebo-controlled study to investigate the pharmacokinetics and safety of trans-resveratrol. In four groups of ten healthy adult subjects (five males and five females), two subjects were randomized to receive placebo and eight subjects to receive trans-resveratrol 25, 50, 100 or 150 mg, six times/day, for thirteen doses. Peak plasma concentrations of trans-resveratrol were reached at 0.8-1.5 h postdose. Following the 13th dose of trans-resveratrol 25, 50, 100 and 150 mg, mean peak plasma concentration (C(max)) was 3.89, 7.39, 23.1 and 63.8 ng/mL and mean area under the plasma concentration-time curve (AUC(0-tau)) was 3.1, 11.2, 33.0 and 78.9 ng.h/mL. Interindividual variability was high, with coefficients of variation >40%. Trans-resveratrol half-life was 1-3 h following single-doses and 2-5 h following repeated dosing. Trough (C(min)) concentrations were < or = 1 ng/mL following 25 and 50 mg, 3 ng/mL following 100 mg and < 10 ng/mL following 150 mg. Trans-resveratrol pharmacokinetics showed circadian variation. Adverse events were mild in severity and similar between all groups. In conclusion, repeated administration was well-tolerated but produced relatively low plasma concentrations of trans-resveratrol, despite the high doses and short dosing interval used. Bioavailability was higher after morning administration.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Biological Availability
  • Circadian Rhythm
  • Double-Blind Method
  • Female
  • Humans
  • Kinetics
  • Male
  • Placebos
  • Resveratrol
  • Stilbenes / administration & dosage
  • Stilbenes / adverse effects*
  • Stilbenes / pharmacokinetics*


  • Placebos
  • Stilbenes
  • Resveratrol