The role of the lipogenic pathway in the development of hepatic steatosis

Diabetes Metab. 2008 Dec;34(6 Pt 2):643-8. doi: 10.1016/S1262-3636(08)74599-3.


Non-alcoholic fatty liver disease (NAFLD) represents a wide spectrum of diseases, ranging from simple fatty liver (hepatic steatosis) through steatosis with inflammation and necrosis to cirrhosis. NAFLD, which is strongly associated with obesity, insulin resistance and type 2 diabetes, is now well recognized as being part of the metabolic syndrome. The metabolic pathways leading to the development of hepatic steatosis are multiple, including enhanced non-esterified fatty acid release from adipose tissue (lipolysis), increased de novo fatty acids (lipogenesis) and decreased beta-oxidation. Recently, several mouse models have helped to clarify the molecular mechanisms leading to the development of hepatic steatosis in the pathogenesis of NAFLD. This review describes the models that have provided evidence implicating lipogenesis in the development and/or prevention of hepatic steatosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dietary Fats / metabolism
  • Disease Models, Animal
  • Disease Progression
  • Fatty Liver / complications
  • Fatty Liver / pathology
  • Fatty Liver / physiopathology*
  • Gene Expression Regulation
  • Humans
  • Insulin Resistance
  • Lipids / physiology*
  • Liver Cirrhosis / genetics
  • Liver Cirrhosis / pathology
  • Mice
  • Necrosis
  • Sterol Regulatory Element Binding Protein 1 / genetics


  • Dietary Fats
  • Lipids
  • Sterol Regulatory Element Binding Protein 1