Perceived medication adverse effects and coping strategies reported by chronic heart failure patients

Int J Clin Pract. 2009 Feb;63(2):233-42. doi: 10.1111/j.1742-1241.2008.01954.x.


Background: Data on medication adverse effects (AEs) in chronic heart failure (CHF) are primarily based on results from clinical trials. Little is known about AEs perceived by CHF patients in daily practice and how patients deal with these subjective AEs.

Aims: To describe the scope and nature of perceived AEs of CHF patients, their coping strategies and the relationship of perceived AEs to medication, patient characteristics and quality of life.

Methods: This cross-sectional observational study included a sample of 680 patients previously hospitalised for CHF. Perceived AEs and coping strategies were collected by interviews based on a structured questionnaire. Medication and clinical information were collected by chart review.

Results: Of the 670 CHF patients completing the questionnaire, 17% reported at least one AE. In total, 186 AEs were reported of which 15% could not be linked to any medication. Nausea (4%), dizziness (4%), itches (3%) and rash (3%) were the most prevalent. The drug associated with the highest AE rate was pravastatin (27%). On average, more than five different drugs could be related to the AEs headache, dizziness and nausea. Patients reporting AEs had a lower general health perception, younger age and were more often using antiarrhythmic drugs. Of patients experiencing AEs, 69% conferred with their doctor, 24% reported having done nothing in reaction and 2% discontinued their medication without discussing it with the doctor.

Conclusion: Adverse effects are frequently perceived by CHF patients, but they are difficult to recognise and manage in daily practice.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Psychological*
  • Aged
  • Attitude to Health
  • Cardiovascular Agents / adverse effects*
  • Chronic Disease
  • Counseling
  • Female
  • Fibrinolytic Agents / adverse effects
  • Heart Failure / drug therapy*
  • Heart Failure / psychology
  • Humans
  • Male
  • Patient Education as Topic
  • Perception


  • Cardiovascular Agents
  • Fibrinolytic Agents