Vitamin D3 is not effective in the treatment of chronic chilblains

Int J Clin Pract. 2009 Feb;63(2):282-6. doi: 10.1111/j.1742-1241.2008.01912.x.


Background: Chronic chilblains is a common disease causing major restrictions in daily life, nevertheless little is known about effective treatment. In a literature search, we found thin evidence of three interventions: fluocinolone cream, nifedipine and vitamin D3.

Objective: We have conducted a study to assess the effect of oral administration of 2000 IU vitamin D3 per day on patients suffering from chronic chilblains.

Methods: The study was based on a self-controlled design. The study population consisted of patients with a confirmed diagnosis. Outcome measurement was the change in severity of the complaints and disability. We checked for interference by temperature and other confounders.

Limitations: The size of the cohort (n = 33) was a limitation.

Results: After correction for confounding factors, 19% of the subjects reported fewer complaints and 6% fewer disability, in both the placebo and vitamin D3 treatment groups.

Conclusion: Oral administration of 2000 IU vitamin D3 per day is not better than placebo in the treatment of patients with chronic chilblains.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Chilblains / drug therapy*
  • Cholecalciferol / therapeutic use*
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Treatment Failure
  • Vitamins / therapeutic use*
  • Young Adult


  • Vitamins
  • Cholecalciferol