Previous research suggests that there is a great deal of variability among older adults' response to memory training. Using latent class analysis, we examined data from the memory training arm of the Advanced Cognitive Training for Independent and Vital Elderly Trial (ACTIVE), a large randomized controlled cognitive training trial, to determine if there were distinct patterns of responsiveness to training. Additionally, we examined whether baseline demographic and cognitive factors were predictive of these response patterns. The results indicate that among memory-trained participants, there are 3 distinct response patterns, suggesting that participants gravitate toward specific mnemonic techniques. Furthermore, baseline memory and speed of processing abilities, age, and education are predictive of these distinct response patterns. Taken together, the findings suggest that we can characterize and predict older adults' response to memory training.