Clinical and diagnostic features of delayed hypoxic leukoencephalopathy

J Neuropsychiatry Clin Neurosci. Fall 2008;20(4):473-7. doi: 10.1176/jnp.2008.20.4.473.

Abstract

Delayed hypoxic leukoencephalopathy is an underrecognized syndrome of delayed demyelination, which is important to consider when delayed onset of neuropsychiatric symptoms follows a hypoxic event. The authors describe clinical and diagnostic features of three such cases, review the pathophysiology of delayed hypoxic leukoencephalopathy, and discuss features which may help distinguish it from toxic leukoencephalopathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Analgesics, Opioid / poisoning
  • Benzodiazepines / poisoning
  • Brain / pathology*
  • Cocaine / poisoning
  • Cognition Disorders / etiology
  • Cognition Disorders / pathology
  • Depressive Disorder, Major / pathology
  • Depressive Disorder, Major / psychology
  • Drug Overdose
  • Female
  • Fentanyl / poisoning
  • Fibromyalgia / drug therapy
  • Fibromyalgia / psychology
  • Gait Disorders, Neurologic / chemically induced
  • Gait Disorders, Neurologic / pathology
  • Humans
  • Hypoxia, Brain / chemically induced
  • Hypoxia, Brain / diagnosis*
  • Hypoxia, Brain / pathology*
  • Magnetic Resonance Imaging
  • Methadone / poisoning
  • Middle Aged
  • Motor Neurons / physiology
  • Narcotic Antagonists / poisoning
  • Neuropsychological Tests
  • Psychoses, Substance-Induced / pathology
  • Psychoses, Substance-Induced / psychology
  • Suicide, Attempted

Substances

  • Analgesics, Opioid
  • Narcotic Antagonists
  • Benzodiazepines
  • Cocaine
  • Methadone
  • Fentanyl