Neurosensory mechanotransduction

Nat Rev Mol Cell Biol. 2009 Jan;10(1):44-52. doi: 10.1038/nrm2595.


Neurons that sense touch, sound and acceleration respond rapidly to specific mechanical signals. The proteins that transduce these signals and underlie these senses, however, are mostly unknown. Research over the past decade has suggested that members of three families of channel proteins are candidate transduction molecules. Current studies are directed towards characterizing these candidates, determining how they are mechanically gated and discovering new molecules that are involved in mechanical sensing.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Mechanotransduction, Cellular / physiology*
  • Neurons / physiology*
  • Proteins / physiology*
  • Sodium Channels / metabolism


  • Proteins
  • Sodium Channels