Experimental induction of feline viral rhinotracheitis virus re-excretion in FVR-recovered cats

Vet Rec. 1977 Feb 12;100(7):128-33. doi: 10.1136/vr.100.7.128.

Abstract

The re-excretion of feline viral rhinotracheitis (FVR) virus (feline herpesvirus I) by FVR-recovered cats is recorded both spontaneously and following a variety of stimuli, namely, corticosteroid administration, change of housing, and parturition and lactation. At least 27 of 33 (82%) FVR-recovered cats studied were shown to be viral carriers. The carrier state was characterised by periods of viral latency interspersed with episodes of viral shedding. Administration of 0-75 mg dexamethasone trimethylacetate and 2-25 mg prednisolone on days 0,2 and 4 resulted in re-excretion after a mean lag period of 7-2 days in 22 of 32 (69%) FVR-recovered cats on a total of 31 of 57 (54%) occasions. Rehousing resulted in virus re-excretion after a mean lag period of 7-2 days in four of 22 (18%) cats tested on a total of six of 40 (15%) occasions. Apparently spontaneous shedding occurred on a total of 10 occasions in nine of 31 (29%) cats during a mean observation period of 8-8 months. Four of six FVR-recovered queens in a total of four of 10 litters (40%) shed virus within two to 10 weeks of parturition. Serum neutralising antibody titres were generally boosted at the time of first re-infection but afterwards remained essentially constant. Although 82% of cats in these studies were shown to be viral carriers, only 45% of cats shed virus spontaneously or as a result of the natural stress situations and it is postulted that these naturally excreting cats are of most significance epidemiologically.

MeSH terms

  • Animals
  • Carrier State / microbiology
  • Carrier State / veterinary*
  • Cat Diseases / microbiology*
  • Cats
  • Dexamethasone / pharmacology
  • Female
  • Herpesviridae / isolation & purification
  • Herpesviridae Infections / microbiology
  • Herpesviridae Infections / veterinary*
  • Housing, Animal
  • Labor, Obstetric
  • Lactation
  • Prednisolone / pharmacology
  • Pregnancy
  • Stress, Physiological / veterinary

Substances

  • Dexamethasone
  • Prednisolone