Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

Nat Genet. 2009 Mar;41(3):283-5. doi: 10.1038/ng.314. Epub 2009 Feb 8.


We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoprotein A-II / genetics*
  • Case-Control Studies
  • Coronary Artery Disease / genetics*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Haplotypes
  • Humans
  • Lipoprotein(a) / genetics*
  • Multigene Family
  • Organic Cation Transport Proteins / genetics*
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Risk Factors


  • APOA2 protein, human
  • Apolipoprotein A-II
  • Lipoprotein(a)
  • Organic Cation Transport Proteins
  • solute carrier family 22 (organic cation transporter), member 3