Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

AAPS J. 2009 Mar;11(1):109-19. doi: 10.1208/s12248-009-9084-5. Epub 2009 Feb 6.

Abstract

This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol, synthetic analogs such as ajulemic acid and nabilone, the endogenous cannabinoids anandamide and related compounds, namely, the elmiric acids, and finally, noncannabinoid components of Cannabis that show anti-inflammatory action. It is intended to be an update on the topic of the involvement of cannabinoids in the process of inflammation. A possible mechanism for these actions is suggested involving increased production of eicosanoids that promote the resolution of inflammation. This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that suppress the synthesis of eicosanoids that promote the induction of the inflammatory process.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arachidonic Acids / pharmacology
  • Arachidonic Acids / therapeutic use
  • Cannabinoid Receptor Modulators / pharmacology
  • Cannabinoid Receptor Modulators / therapeutic use*
  • Cannabinoids / chemical synthesis
  • Cannabinoids / pharmacology
  • Cannabinoids / therapeutic use*
  • Cannabis / chemistry
  • Disease Models, Animal
  • Dronabinol / analogs & derivatives
  • Dronabinol / pharmacology
  • Dronabinol / therapeutic use
  • Drug Evaluation, Preclinical
  • Eicosanoids / biosynthesis
  • Eicosanoids / physiology
  • Endocannabinoids*
  • Fibromyalgia / drug therapy
  • Glycine / analogs & derivatives
  • Glycine / pharmacology
  • Glycine / therapeutic use
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / physiopathology
  • Mice
  • Plant Oils / chemistry
  • Randomized Controlled Trials as Topic
  • Rats
  • Receptors, Cannabinoid / drug effects
  • Receptors, Cannabinoid / physiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Arachidonic Acids
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Eicosanoids
  • Endocannabinoids
  • N-arachidonylglycine
  • Plant Oils
  • Receptors, Cannabinoid
  • Dronabinol
  • ajulemic acid
  • Glycine