Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity

J Nat Prod. 2009 Feb 27;72(2):280-3. doi: 10.1021/np800338p.

Abstract

Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology*
  • Chloroquine / pharmacology
  • Cyperaceae / chemistry*
  • Drug Resistance / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Stereoisomerism

Substances

  • Antimalarials
  • Sesquiterpenes
  • okundoperoxide
  • Chloroquine