Treatment of painful diabetic neuropathy with capsaicin 0.075%

J Am Podiatr Med Assoc. 1991 Jun;81(6):288-93. doi: 10.7547/87507315-81-6-288.


An 8-week, double-blind, vehicle-controlled study was conducted to determine the effectiveness of topical capsaicin 0.075% cream in relieving pain associated with diabetic neuropathy. Patients were selected who experienced moderate to very severe pain, which interfered with sleep or activities on a daily basis, and who were unresponsive or intolerant to conventional therapy. The results after 8 weeks showed a statistically significant difference in favor of the capsaicin-treated patients, with 90% of these patients improved. The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Capsaicin / administration & dosage
  • Capsaicin / therapeutic use*
  • Diabetic Neuropathies / complications*
  • Diabetic Neuropathies / diagnosis
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain / diagnosis
  • Pain / drug therapy*
  • Pain / etiology
  • Pain Measurement


  • Capsaicin