Crosstalk between the SUMO and ubiquitin pathways

Ernst Schering Found Symp Proc. 2008;(1):1-16. doi: 10.1007/2789_2008_098.


Several ways in which the SUMO and ubiquitin pathways can intersect and communicate have recently been discovered. This review discusses the principles of crosstalk between SUMOylation and ubiquitination, focusing on the RNF4 family of RING finger E3 ubiquitin ligases, which specifically recognize SUMOylated proteins via their SUMO moiety for ubiquitination.

Publication types

  • Review

MeSH terms

  • Animals
  • Protein Binding
  • RING Finger Domains
  • Signal Transduction*
  • Small Ubiquitin-Related Modifier Proteins / metabolism*
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligases / chemistry
  • Ubiquitin-Protein Ligases / classification
  • Ubiquitin-Protein Ligases / metabolism


  • Small Ubiquitin-Related Modifier Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases