Primary antiphospholipid syndrome: a report of two pediatric cases

J Rheumatol. 1991 Jul;18(7):1085-7.


Two cases of primary antiphospholipid syndrome are described. A girl presented with myocardial infarction at the age of 6. afterward developed chorea, livedo reticularis, thrombocytopenia and circulating lupus anticoagulant (LAC). A boy, age 7, had an episode of intracranial hypertension and a deep venous thrombosis of a lower left limb, both recurrent in the following years. A high titer of IgG anticardiolipin antibodies (aCI) was detected. These observations suggest that both LAC and aCI tests should be performed in children with thromboembolic phenomena when the criteria for a definite autoimmune disease are lacking.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies / analysis
  • Antiphospholipid Syndrome* / complications
  • Antiphospholipid Syndrome* / diagnosis
  • Cardiolipins / immunology
  • Child
  • Cranial Sinuses
  • Female
  • Humans
  • Leg / blood supply
  • Lupus Coagulation Inhibitor / analysis
  • Male
  • Myocardial Infarction / complications
  • Thrombophlebitis / complications


  • Antibodies
  • Cardiolipins
  • Lupus Coagulation Inhibitor