Preparation of unsymmetrical biaryls by Pd(II)-catalyzed cross-coupling of aryl iodides

Liqiang Wang; Wenjun Lu

doi:10.1021/ol802865c

Preparation of unsymmetrical biaryls by Pd(II)-catalyzed cross-coupling of aryl iodides

Org Lett. 2009 Mar 5;11(5):1079-82. doi: 10.1021/ol802865c.

Authors

Liqiang Wang¹, Wenjun Lu

Affiliation

¹ Department of Chemistry, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

PMID: 19203254
DOI: 10.1021/ol802865c

Abstract

The Ullmann homo- and cross-couplings of aryl iodides are carried out to afford symmetrical and unsymmetrical biaryls in moderate to good yields in a catalytic system of Pd(OAc)(2)/K(2)CO(3)/MeCOEt. The high selectivity of unsymmetrical biaryl products in cross-couplings mainly depends on the reactivity difference between two iodoarene substrates and their employed ratios.