Modulation of the efficacy of temozolomide and dacarbazine melanoma treatment by DNA-repair factors in vivo and in vitro

MeSH terms

• Adaptor Proteins, Signal Transducing / genetics
• Adaptor Proteins, Signal Transducing / metabolism
• Antineoplastic Agents, Alkylating / adverse effects
• Antineoplastic Agents, Alkylating / metabolism
• Antineoplastic Agents, Alkylating / therapeutic use*
• Cell Line, Tumor
• Cell Survival / drug effects
• Cell Survival / physiology
• Clinical Trials as Topic
• DNA Modification Methylases / genetics
• DNA Modification Methylases / metabolism
• DNA Repair Enzymes / genetics
• DNA Repair Enzymes / metabolism
• DNA Repair Enzymes / therapeutic use*
• Dacarbazine / adverse effects
• Dacarbazine / analogs & derivatives*
• Dacarbazine / metabolism
• Dacarbazine / therapeutic use*
• Drug Resistance, Neoplasm / drug effects*
• Drug Resistance, Neoplasm / genetics
• Gene Expression Regulation, Neoplastic
• Humans
• Lymphocytes / enzymology
• Lymphocytes / metabolism
• Melanoma / drug therapy*
• Melanoma / metabolism
• Melanoma / pathology
• Methylation
• MutL Protein Homolog 1
• MutS Homolog 2 Protein / genetics
• MutS Homolog 2 Protein / metabolism
• Nuclear Proteins / genetics
• Nuclear Proteins / metabolism
• Prodrugs / metabolism
• Promoter Regions, Genetic
• RNA, Messenger / genetics
• RNA, Messenger / metabolism
• Temozolomide
• Tumor Suppressor Proteins / genetics
• Tumor Suppressor Proteins / metabolism