An amino acid shuffle activates mTORC1

Cell. 2009 Feb 6;136(3):399-400. doi: 10.1016/j.cell.2009.01.021.

Abstract

The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy
  • Glutamine / metabolism*
  • Humans
  • Large Neutral Amino Acid-Transporter 1 / metabolism
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes
  • Protein Kinases / metabolism*
  • Proteins
  • TOR Serine-Threonine Kinases
  • Transcription Factors / metabolism

Substances

  • Large Neutral Amino Acid-Transporter 1
  • Multiprotein Complexes
  • Proteins
  • Transcription Factors
  • Glutamine
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Mechanistic Target of Rapamycin Complex 1