Abstract
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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CD8-Positive T-Lymphocytes / drug effects*
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CD8-Positive T-Lymphocytes / immunology
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Cell Line, Tumor
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Cinnamomum zeylanicum*
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Cyclooxygenase 2 Inhibitors / pharmacology
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Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors
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Intercellular Signaling Peptides and Proteins / analysis
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Intercellular Signaling Peptides and Proteins / genetics
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Male
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Melanoma, Experimental / drug therapy*
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Melanoma, Experimental / pathology
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Mice
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Mice, Inbred C57BL
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Neovascularization, Pathologic / drug therapy*
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Plant Extracts / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Cyclooxygenase 2 Inhibitors
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Hif1a protein, mouse
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Hypoxia-Inducible Factor 1, alpha Subunit
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Intercellular Signaling Peptides and Proteins
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Plant Extracts