Central quadrant procurement of radical prostatectomy specimens

Prostate. 2009 May 15;69(7):770-3. doi: 10.1002/pros.20925.


Obtaining high quality fresh or frozen prostate tissue in gram amounts promotes the research of prostate cancer. Due to the inability to effectively recognize prostate cancer upon the cut section of a fresh prostate many pathology departments perform whole organ processing precluding the procurement of prostate tissue. Some sites randomly procure tissue, while others perform specialized procedures that can be difficult to duplicate. Neither of these types of procurement consistently results in gram quantities of tissue procured from each prostate with a high percentage of samples yielding tissue corresponding to cancer. In this study, we present a simplified model of prostate tissue procurement that has no impact on Gleason grade, tumor stage or margin status, requires minimal specialized processing, and obtains gram amounts of fresh tissue from each radical prostatectomy specimen with a high percentage yielding cancer tissue.

MeSH terms

  • Humans
  • Male
  • Neoplasm Staging
  • Prostatectomy / methods*
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery
  • RNA, Neoplasm / chemistry
  • RNA, Neoplasm / genetics
  • Specimen Handling / methods*


  • RNA, Neoplasm