Familial associations between polycystic ovarian syndrome and common diseases

J Assist Reprod Genet. 2009 Mar;26(2-3):123-7. doi: 10.1007/s10815-009-9297-7. Epub 2009 Feb 10.


Purpose: The goal of this study was focused on two subjects. First, to determine possible association between PCOS and family history of breast cancer, ovarian cancer, endometrial cancer, heart attack, thrombosis, diabetes and cardiovascular disease (CVD). Second, to evaluate maternal and paternal transmission in PCOS patients with positive family history of a disease.

Methods: A cross-sectional study was conducted in 549 infertile women (273 with PCOS and 276 controls) in Arash hospital of Tehran, Iran, between 2007 and 2008 by using questionnaire.

Results: In this analysis, there were significantly increased number of women with the positive family history of diabetes among PCOS group (28.21% vs. 19.20%, p=0.01). Meanwhile, four women in PCOS group had self history of diabetes while no one in the control group reported diabetes. A statistically significant positive family history of breast cancer was found among the control group (4.35% vs. 1.30%, p=0.02). Endometrial cancer and diabetes were observed in mother or mother's side of the family but heart attack and thrombosis manifested in father or father's side of the family more. There were no statistically significant differences in a positive individual or family history of ovarian cancer, endometrial cancer, heart attack, thrombosis and CVD between the two groups.

Conclusion: In the present study, women and their relatives with PCOS had an increased prevalence of diabetes and it is more common in mother's side of the family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics
  • Cross-Sectional Studies
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / genetics
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / genetics
  • Family Health
  • Female
  • Heart Arrest / epidemiology
  • Heart Arrest / genetics
  • Humans
  • Infertility, Female / epidemiology
  • Infertility, Female / etiology
  • Infertility, Female / genetics
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / epidemiology*
  • Polycystic Ovary Syndrome / genetics
  • Surveys and Questionnaires
  • Thrombosis / epidemiology
  • Thrombosis / genetics