The Seattle Virus Watch. VII. Observations of Adenovirus Infections

Am J Epidemiol. 1977 Apr;105(4):362-86. doi: 10.1093/oxfordjournals.aje.a112394.

Abstract

The following findings were made from observations of adenovirus (AV) infections in Seattle VW families, 1965-1969, which extended the 1961-1965 New York VW studies: That infections are predominantly enteric, may be abortive or invasive and followed by persistent intermittent excretion was confirmed. That such excretion is most characteristic of types 1, 2, 3 and 5 viruses may explain why these types were usually endemic. However, since observed duration of excretion was not increased despite a longer average observation period, persistent excretion appears not to continue indefinitely and generation-to-generation transmission now seems improbable. Unilike New York, alternate cycling of types 1 and 2 viruses was not seen. Among homotypic susceptibles, infection rates for the endemic types were highest in infants (greater than 90% for types 1 and 2), decreased with age in older children but increased in parents, perhaps because of closer contact with infants. Development of serum neutralizing antibody was most frequent (about 90%) after types 1 and 2 infection; in all cases, titers decayed over time. While delayed virus spread related to persistent intermittent excretion did occur, spread closely following new or renewed (after larger than or equal to 3 months) excretion was more important. Sibling introducers were more effective spreaders than infants, and duration of excretion was more important than mode. These data indicate that homotypic immunity is 85% protective against infection. A protective effect of heterotypic immunity could not be shown. Illness (chiefly respiratory and often febrile) was associated with 49% of infections in susceptibles and with 65% when respiratory shedding occurred. The contribution of AV to all infectious illness, based on virus-positive infections only, was 5% in infants and 3% in the 2-4-year age group; for febrile illness, the corresponding contributions were about 10% and 5%. Inclusion of infections discovered only be serology (49% of all infections) would greatly increase the contribution of AV to illness.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae / isolation & purification
  • Adenoviridae Infections* / epidemiology
  • Adenoviridae Infections* / immunology
  • Adenoviridae Infections* / microbiology
  • Adenovirus Infections, Human* / epidemiology
  • Adenovirus Infections, Human* / immunology
  • Adenovirus Infections, Human* / microbiology
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / analysis
  • Child
  • Child, Preschool
  • Feces / microbiology
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • New York
  • Recurrence
  • Respiratory System / microbiology
  • Seasons
  • Time Factors
  • Washington

Substances

  • Antibodies, Viral