The interface between obesity and periodontitis with emphasis on oxidative stress and inflammatory response

Obes Rev. 2009 May;10(3):290-7. doi: 10.1111/j.1467-789X.2008.00555.x. Epub 2009 Jan 16.


Obesity is characterized by the abnormal or excessive deposition of fat in the adipose tissue. Its consequences go far beyond adverse metabolic effects on health, causing an increase in oxidative stress that leads not only to endothelial dysfunction but also to negative effects in relation to periodontitis, because of the increase in proinflammatory cytokines. Thus, obesity appears to participate in the multifactorial phenomenon of causality of periodontitis through the increased production of reactive oxygen species. Within this context, this paper aims to highlight, by analysis and description of previous studies, the interface between obesity and periodontitis, with emphasis on oxidative stress and the inflammatory response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Inflammation / metabolism*
  • Obesity / metabolism*
  • Oxidative Stress*
  • Periodontitis / metabolism*