Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome

Pediatr Infect Dis J. 2009 Mar;28(3):254-5. doi: 10.1097/INF.0b013e31818c8ea5.

Abstract

PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis) is a benign sporadic syndrome of unknown cause. We report 2 siblings diagnosed with this syndrome. The second case started crisis simultaneously with recurrence of crisis after a 3-year free interval in her brother. This temporal relation suggests environmental factor acting in genetically predisposed children.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Fever of Unknown Origin / complications*
  • Fever of Unknown Origin / drug therapy
  • Glucocorticoids / therapeutic use
  • Humans
  • Lymphadenitis* / complications
  • Lymphadenitis* / diagnosis
  • Lymphadenitis* / drug therapy
  • Male
  • Periodicity*
  • Pharyngitis* / complications
  • Pharyngitis* / diagnosis
  • Pharyngitis* / drug therapy
  • Prednisone / therapeutic use
  • Siblings*
  • Stomatitis, Aphthous / complications
  • Stomatitis, Aphthous / diagnosis
  • Stomatitis, Aphthous / drug therapy
  • Syndrome

Substances

  • Glucocorticoids
  • Prednisone