A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch

J Invest Dermatol. 2009 Mar;129(3):531-5. doi: 10.1038/jid.2008.440.


Pruritus in eczema and other inflammatory skin diseases is an unsolved problem. Recent findings strongly indicate that histamine is not the only mediator of pruritus. Subtypes of the transient receptor potential (TRP) ion channel superfamily are expressed by sensory nerves, keratinocytes, and certain leukocytes. Temperature, pH changes, and certain toxins activate TRPs. New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Temperature
  • Humans
  • Hydrogen-Ion Concentration
  • Inflammation / immunology*
  • Inflammation / therapy*
  • Keratinocytes / metabolism
  • Leukocytes / metabolism
  • Mice
  • Mice, Transgenic
  • Pruritus / immunology*
  • Pruritus / therapy*
  • Skin / pathology
  • TRPV Cation Channels / metabolism*
  • Transient Receptor Potential Channels / metabolism*
  • Transient Receptor Potential Channels / physiology


  • TRPV Cation Channels
  • TRPV3 protein, human
  • Transient Receptor Potential Channels
  • Trpv3 protein, mouse