Pulmonary alveolar proteinosis in a patient with Behcet's disease

Respirology. 2009 Mar;14(2):305-8. doi: 10.1111/j.1440-1843.2008.01450.x. Epub 2008 Dec 11.


Secondary pulmonary alveolar proteinosis (PAP) has been described in several clinical settings that can be grouped into three main categories: infections of the lung; haematological malignancies and other conditions that alter the patient's immune status; and exposure to inhaled chemicals and minerals. Recent studies reported that anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody was present in the serum of patients with idiopathic PAP but not in patients with secondary PAP or in normal subjects. The present report describes the interesting case of a patient with Behcet's disease and PAP. The absence of anti-GM-CSF antibodies in this patient suggested a diagnosis of secondary PAP.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies / blood
  • Antibodies / immunology
  • Behcet Syndrome / complications*
  • Female
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology
  • Humans
  • Pulmonary Alveolar Proteinosis / blood
  • Pulmonary Alveolar Proteinosis / diagnosis*
  • Pulmonary Alveolar Proteinosis / etiology*


  • Antibodies
  • Granulocyte-Macrophage Colony-Stimulating Factor