PDLIM4, an actin binding protein, suppresses prostate cancer cell growth

Cancer Invest. 2009 Mar;27(3):264-72. doi: 10.1080/07357900802406319.


We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Actins / analysis
  • Animals
  • Cell Line, Tumor
  • DNA-Binding Proteins / analysis
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Humans
  • LIM Domain Proteins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Microfilament Proteins
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / prevention & control*
  • Tumor Suppressor Proteins / physiology*


  • Actins
  • DNA-Binding Proteins
  • LIM Domain Proteins
  • Microfilament Proteins
  • PDLIM4 protein, human
  • Pdlim4 protein, mouse
  • Tumor Suppressor Proteins