Stiffness Parameters, Intima-Media Thickness and Early Atherosclerosis in Systemic Lupus Erythematosus Patients

Lupus. 2009 Mar;18(3):249-56. doi: 10.1177/0961203308097571.

Abstract

Detection of early carotid vascular disease in patients with systemic lupus erythematosus (SLE) is considered mandatory for evaluation of subclinical atherosclerosis (ATS), and various ultrasonographic (US) parameters have been proposed. In the present investigation, 33 SLE and 33 healthy age-matched females have been studied by colour-coded sonography of the common carotid artery, assessing intima-media thickness (IMT), vascular strain (VS), vascular distensibility (VD), vascular stiffness (VSf) and pressure-strain elastic modulus (PSEM) as possible markers of early ATS. Patients with SLE, despite equivalent exposure to "traditional" cardiovascular risk factors, presented a higher mean IMT of the common carotid artery than healthy subjects (0.7 +/- 0.2 mm vs 0.5 +/- 0.1 mm - P < 0.0001). Of the stiffness parameters, patients with lupus showed a mean VSf of 0.72 +/- 0.38 vs 0.54 +/- 0.14 in controls (P < 0.0001) and a mean PSEM of 6.0 +/- 2.8 Pa vs 3.0 +/- 1.4 Pa in controls (P < 0.0001). Mean VS and VD were significantly lower in patients with SLE than in healthy subjects (P < 0.0001). Among individuals with IMT < 0.6 mm, patients with SLE presented more compromised stiffness parameters. IMT was shown to be a useful parameter in the evaluation of vascular damage, even in a "sub-clinical" phase, while stiffness parameters provide additional details regarding endothelial and vessel functional state. Combined evaluation may allow ATS to be detected in the early stages in patients with SLE.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Atherosclerosis / diagnostic imaging
  • Atherosclerosis / pathology*
  • Blood Flow Velocity
  • Elastic Modulus
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / diagnostic imaging
  • Lupus Erythematosus, Systemic / pathology*
  • Middle Aged
  • Risk Factors
  • Severity of Illness Index
  • Tunica Intima / anatomy & histology*
  • Tunica Intima / diagnostic imaging
  • Tunica Intima / pathology
  • Tunica Media / anatomy & histology*
  • Tunica Media / diagnostic imaging
  • Tunica Media / pathology
  • Ultrasonography
  • Vascular Diseases / diagnostic imaging
  • Vascular Diseases / pathology
  • Young Adult