Abstract
(+/-)-Neovibsanin B was synthesized based on a DMI-accelerated intramolecular Diels-Alder reaction followed by oxy-Michael addition-lactonization. The synthetic (+/-)-neovibsanin B induced similar morphological changes in NGF-mediated PC12 cells compared with natural (+)-neovibsanin B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Diterpenes / chemical synthesis*
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Diterpenes / chemistry
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Diterpenes / pharmacology
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Molecular Structure
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Nerve Growth Factor / chemical synthesis*
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Nerve Growth Factor / chemistry
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Nerve Growth Factor / pharmacology
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Neurites / drug effects*
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PC12 Cells
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Rats
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Stereoisomerism
Substances
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Diterpenes
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neovibsanin A
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Nerve Growth Factor