In vivo tracking of cellular therapeutics using magnetic resonance imaging

Expert Opin Biol Ther. 2009 Mar;9(3):293-306. doi: 10.1517/14712590802715723.


Background: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy.

Objective: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology.

Methods: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease.

Results/conclusion: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Immunotherapy*
  • Magnetic Resonance Imaging / methods*
  • Neoplasms / therapy*
  • Staining and Labeling
  • Stem Cell Transplantation*
  • Stem Cells / cytology*